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KMID : 0357919860200040496
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Korean Journal of Pathology
1986 Volume.20 No. 4 p.496 ~ p.502
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Pure Epithelioid Malignant Schwanoma
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김혜연/Hye Yeon Kim
이규범/김인선/이갑노/백승룡/Kyu Bum Lee/In Sun Kim/Kap No Lee/Seung Yong Paik
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Abstract
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The Pure epithelioid malignant schwanoma is a rare form of malignant schwanoma and
differs from the ordinal epithelioid malignant schwanoma because of the absence of a
spindle cell component. We present a case of purely epithelioid malignant schwanoma
arising in the parapharyngeal area from vagus nerve without definite evidence of von
Recklinghausen's disease.
The patient was a 28-year-old man with palpable right neck mass and swallowing
difficulty during 2 years. The mass was an ovoid encapsulated tumor and measured 5×
3×3 ㎝ in dimension. The cut surface showed brownish tan homogeneous nodular
appearance with partly myxoid area. Microscopically the tumor showed nodular pattern
composed of epithelioid cells which were arranged in both tight clusters and stringy
cords. The cells were ovoid in shape and had vesicular nuclei with single prominent
eosinophilic nucleolei and sometime abundant intracytoplasmic mucin. Mitoses were
infrequent. Ultrastructural study showed rudimentary cell junction and degenerated
cytoplasmic organelles including scattered mitochondriae, short segments of rough
endoplasmic reticulum and lipid droplets. There were no definite basement membrane
and melanosome. Immunohistochemical study showed the cells being positive for S100
protein, neuron specific enolase and myelin basic protein and negative for cytokeratin.
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